TIM3 antibody (FITC)

Catalog No. ABIN308140

This Rat Monoclonal antibody specifically detects TIM3 in FACS and IHC. It exhibits reactivity toward Mouse.

Quick Overview for TIM3 antibody (FITC) (ABIN308140)

Target: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This TIM3 antibody is conjugated to FITC

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC)

Clone: 25F-1D6

Product Details anti-TIM3 Antibody (FITC)

Specificity: Anti-mouse Tim-3 (T cell immunoglobulin domain, mucin domain 3) monoclonal antibody reacts with mouse Tim-3. This 281 amino acid type 1 transmembrane protein contains an immunoglobulin and mucin-like domain in its extra-cellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. Tim-3 is a member of the immunoglobulin super-family and is expressed on Th1 lymphocytes and CD11b+ macrophages. Tim-3 is a T helper type 1 (TH1)-specific molecule that regulates TH1 mediated auto and alloimmune responses and the induction of peripheral immunological tolerance. This antibody has been reported to work in Flow Cytometry and Immunohistochemistry. This FITC conjugated format is especially useful for direct flow cytometry.

Purification: Purified

Immunogen: Murine T cell clone AE7 cells.

Isotype: IgG2a kappa

Application Details

Application Notes: Approved: Flo (1 μg/10 x10⁶), IHC

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Mouse

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.02 % sodium azide, EIA grade BSA.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles and prolonged exposure to light. Store undiluted.

Storage: 4 °C,-20 °C

Storage Comment: Short term: store at 4°C. Long term: aliquot and store -20°C. Avoid freeze-thaw cycles. Protect from light. Store undiluted.

Target Details for TIM3

Target: TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Alternative Name: HAVCR2 / TIM-3

Target Type: Virus

Background: Name/Gene ID: HAVCR2

Synonyms: HAVCR2, HAVcr-2, KIM-3, Kidney injury molecule-3, T cell immunoglobulin mucin 3, Tim-3, TIMD3, T-cell membrane protein 3, TIM3, TIMD-3, T cell immunoglobulin mucin-3

Gene ID: 84868

UniProt: Q8TDQ0

Pathways: Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints