Cathepsin L antibody (AA 114-333)

Catalog No. ABIN317508

Product Details anti-Cathepsin L Antibody

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Binding Specificity: AA 114-333

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cathepsin L antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: The antibody recognizes Human Cathepsin L. Other species not tested.

Characteristics: Synonyms: CTSL1, CTSL, MEP, Cathepsin-L1, Major excreted protein

Purification: Protein-G affinity chromatography

Immunogen: Recombinant Human Cathepsin L (114-333 aa) purified from E. coli

Clone: 2H7

Isotype: IgG2b

Application Details

Application Notes: ELISA. Western blot: 1/1000-1/2000. Immunohistochemistry on Paraffin Sections: 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

References for anti-Cathepsin L antibody (ABIN317508)

Zheng, Chu, Chou, Gallati, Dier, Mirkin, Mousa, Rebbaa: "Cathepsin L inhibition suppresses drug resistance in vitro and in vivo: a putative mechanism." in: American journal of physiology. Cell physiology, Vol. 296, Issue 1, pp. C65-74, (2009) (PubMed).

Target Details for Cathepsin L

Target: Cathepsin L (CTSL1) (Cathepsin L1 (CTSL1))

Alternative Name: Cathepsin L1 (CTSL1 Products)

Background: Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases. Cathepsin L can be induced by many different signaling events, including growth factor, secondary messenger and tumor promoters. Cathepsin L is translated as pre-procathepsin L, transferred through the Golgi apparatus as procathepsin L and then stored in lysosomes as mature cathepsin L.Synonyms: CTSL, CTSL1, Cathepsin-L1, MEP, Major excreted protein

Gene ID: 1514

UniProt: P07711

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades