Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

ITGA4 antibody (Integrin alpha 4) Primary Antibody

ITGA4 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN317659
$513.70
Plus shipping costs $45.00
0.1 mg
local_shipping Shipping to: United States
Available
  • Target
    ITGA4
    Reactivity
    • 148
    • 116
    • 39
    • 19
    • 11
    • 9
    • 9
    • 8
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 73
    • 68
    • 65
    • 1
    • 1
    Rabbit
    Clonality
    • 143
    • 65
    • 1
    Polyclonal
    Conjugate
    • 97
    • 25
    • 24
    • 15
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITGA4 antibody is un-conjugated
    Application
    • 147
    • 50
    • 47
    • 45
    • 38
    • 23
    • 23
    • 12
    • 12
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    This antibody detects endogenous levels of Integrin alpha 4 (ITGA4/CD49d) protein.(region surrounding asn1023)
    Purification
    Affinity Chromatography using epitope-specific immunogen.
  • Application Notes
    ELISA: 1/5000-1/10000. Western Blot: 1/500-1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ITGA4
    Alternative Name
    CD49d / ITGA4 (ITGA4 Antibody Abstract)
    Synonyms
    CD49D, IA4, LOC100219853, integrin subunit alpha 4, integrin alpha 4, integrin subunit alpha 4 S homeolog, ITGA4, Itga4, itga4.S
    Background
    Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery.Synonyms: CD49 antigen-like family member D, Integrin alpha-4, Integrin alpha-IV, VLA-4, VLA4
    Molecular Weight
    approx. 115 kDa
    Gene ID
    3676
    NCBI Accession
    NP_000876
    UniProt
    P13612
    Pathways
    Integrin Complex
You are here:
help Support