Tetanus Toxin antibody

Catalog No. ABIN318666

This anti-Tetanus Toxin antibody is a Goat Polyclonal antibody detecting Tetanus Toxin in WB and EIA. Suitable for Clostridium tetani.

Quick Overview for Tetanus Toxin antibody (ABIN318666)

Target: Tetanus Toxin (TetX)

Reactivity: Clostridium tetani

Host: Goat

Clonality: Polyclonal

Conjugate: This Tetanus Toxin antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-Tetanus Toxin Antibody

Specificity: This antibody detects the tetanus toxin which is produced by the soil micro-organism Clostridium tetani. C. tetani infection results in its systemic growth and secretion of tetanus, which causes muscle spasms by inhibiting neurotransmitter release. The antibody also reacts with the C-fragment of tetanus toxin.

Purification: Affinity Chromatography.

Immunogen: Tetanus Exotoxin

Isotype: IgG

Application Details

Application Notes: ELISA: 1g/mL. Western Blot: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 5.0 mg/mL

Buffer: PBS pH 7.2 containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Tetanus Toxin

Target: Tetanus Toxin (TetX)

Alternative Name: Tetanus Toxin

Target Type: Bacteria

Background: Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the 76-Gln-|-Phe-77 bond of synaptobrevin-2. The precursor polypeptide is subsequently cleaved to yield subchains L and H. These remain linked by a disulfide bridge and are non-toxic after separation.Synonyms: Clostridium tetani toxin, tetX

Gene ID: 1061100

NCBI Accession: NP_783831

UniProt: P04958