RNF34 antibody (N-Term)

Catalog No. ABIN318868

This Rabbit Polyclonal antibody specifically detects RNF34 in WB and EIA. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog and Primate.

Quick Overview for RNF34 antibody (N-Term) (ABIN318868)

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Reactivity: Human, Mouse, Rat, Cow, Dog, Primate

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF34 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-RNF34 Antibody

Binding Specificity: AA 1-373, N-Term

Specificity: This antibody detects Ring Finger homologous to Inhibitor of apoptosis protein (hRFI).

Purification: Purified

Immunogen: Recombinant protein corresponding to amino acids 1-373 of human RFI.

Isotype: IgG

Application Details

Application Notes: ELISA: 1800 - 1: 4000. Western Blot: 1: 100 - 1: 600, detects a band of approximately 42 kDa.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0mg/mL

Buffer: Phosphate buffered saline pH 7.2 containing 0.01 % Sodium Azide (NaN3)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RNF34

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Alternative Name: RFI / RNF34

Background: RFI is an anti-apoptotic protein which has been shown to be a novel modulator of NF-kB activation, leading to the upregulation of Bcl2 and BclXL. It is also thought to possess E3 ubiquitin protein ligase activity and has been shown to target caspases 8 and 10 for proteasomal degradation. hRFI is expressed ubiquitously, and has been localized to both the nucleus and the cytoplasm. hRFI is also expressed in oesophageal, gastric and colorectal cancers, suggesting a possible association between hRFI and the development of digestive tract cancers.Synonyms: CARP-1, CARP1, Caspases-8 and -10-associated RING finger protein 1, E3 ubiquitin-protein ligase RNF34, FYVE-RING finger protein Momo, Human RING finger homologous to inhibitor of apoptosis protein, RIFF

Gene ID: 80196

NCBI Accession: NP_079402

UniProt: Q969K3