Amylin/DAP antibody

Catalog No. ABIN334637

The Chicken Polyclonal anti-Amylin/DAP antibody has been validated for WB and ELISA. It is suitable to detect Amylin/DAP in samples from Human.

Quick Overview for Amylin/DAP antibody (ABIN334637)

Target: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Reactivity: Human

Host: Chicken

Clonality: Polyclonal

Conjugate: This Amylin/DAP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Amylin/DAP Antibody

Characteristics: Expected / apparent Molecular Weight of the Antigene: 4 kDa

Purification: affinity purified

Immunogen: synthetic peptide based on human IAPP sequence: K-C-N-T-A-T-C-A-T-Q-R-L-A-N-F-L-V-H-S-S-N-N-F-G-A-I-L-S-S-T-N-V-G-S-N-T-Y

Isotype: IgY

Application Details

Application Notes: Recommended Dilution: 1 : 1000 (WB), 1 : 1000 (ELISA).

Comment:

antibody is recognizing trimer, dimer and monomer human IAPP

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 8.0 + 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from liquid material adhering to the cap or sides of the tubes.
Make aliquots to avoid repreated freeze-thaw cycles and working with a stock.

Storage: 4 °C

Target Details for Amylin/DAP

Target: Amylin/DAP (IAPP) (Islet Amyloid Polypeptide (IAPP))

Alternative Name: IAPP

Background: Amylin, or Islet Amyloid Polypeptide (IAPP) P10997, is a 37-residue peptide hormone secreted by pancreatic beta-cells at the same time as insulin (in a roughly 1:100 amylin:insulin ratio). Islet, or insulinoma, almyloid polypeptide (IAPP, or amylin) is commonly found in pancreatic islets of patients suffering diabetes mellitus type 2, or harboring an insulinoma. While the association of amylin with the development of type 2 diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Recent results suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzherimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the deleopment of type 2 diabetes.

Molecular Weight: 4 kDa

Pathways: Hormone Activity, Feeding Behaviour