CEA antibody

Catalog No. ABIN335404

This Mouse Monoclonal antibody specifically detects CEA in WB, IHC, FACS, IHC (p), ICC and IHC (fro). It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for CEA antibody (ABIN335404)

Target: CEA (Carcinoembryonic Antigen Gene Family (CEA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CEA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: PARLAM 4

Product Details anti-CEA Antibody

Specificity: Human.

Immunogen: PARLAM 4 is a mouse monoclonal IgG1 antibody derived by fusion of Sp 2/0 Ag 14 mouse myeloma cells with spleen cells from a BABL/c mouse immunized with isolated human CEA. The immunogen has been isolated from human colonic carcinoma cells.

Isotype: IgG1

Application Details

Application Notes: Most polyclonal CEA antisera show cross-reactivity with related antigens such as biliary glycoprotein (BGP) and non-specific cross-reacting antigen 1/11 (NCA). PARLAM 4 does not show cross reactivity, neither with BGP nor with NCA. In immunoblotting the antibody recognizes a single band of 180 kD.

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-CEA antibody (ABIN335404)

Taal, Hageman, Delemarre, Bonfrèr, den Hartog Jager: "Metastatic ovarian or colonic cancer: a clinical challenge." in: European journal of cancer (Oxford, England : 1990), Vol. 28, Issue 2-3, pp. 394-9, (1992) (PubMed).

Henzen-Logmans, Schipper, Poels, Stolk, Kenemans, Meyer: "Use of statistical evaluation of antigen profiles in differential diagnosis between colonic and ovarian adenocarcinomas." in: Journal of clinical pathology, Vol. 41, Issue 6, pp. 644-9, (1988) (PubMed).

Verstijnen, Arends, Moerkerk, Warnaar, Hilgers, Bosman: "CEA-specificity of CEA-reactive monoclonal antibodies. Immunochemical and immunocytochemical studies." in: Anticancer research, Vol. 6, Issue 1, pp. 97-104, (1986) (PubMed).

Target Details for CEA

Target: CEA (Carcinoembryonic Antigen Gene Family (CEA))

Alternative Name: Carcinoembryonic Antigen / CEA

Background: This monoclonal antibody is reactive with human carcinoembryonic antigen (CEA), a tumour associated antigen with oncofetal characteristics. Although CEA can be found in tissues of non-neoplastic diseases and normal epithelia, it occurs also in a large variety of carcinomas. Therefore, immunohistochemical detection of CEA is frequently used for the histopathological diagnosis of human tumours.