c-FOS antibody

Catalog No. ABIN350206

This Sheep Polyclonal antibody specifically detects c-FOS in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for c-FOS antibody (ABIN350206)

Target: c-FOS (c-Fos) (c-Fos)

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Conjugate: This c-FOS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-c-FOS Antibody

Purpose: Sheep antibody to cFos

Specificity: Specific for cFos.

Cross-Reactivity: Human, Marmoset, Mouse, Rat

Cross-Reactivity (Details): Other species not yet tested.

Purification: IgG

Immunogen: A synthetic peptide from human cFos protein conjugated to blue carrier protein has been used as the antigen.

Isotype: IgG

Application Details

Application Notes: IHC WB. Use at a concentration of 10-50 μg,ml. The optimal working concentration should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for c-FOS

Target: c-FOS (c-Fos) (c-Fos)

Alternative Name: cFos

Background: FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction cell proliferation and differentiation. SUBUNIT: Heterodimer. Interacts with DSIPI, this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB SUBCELLULAR LOCATION: Nucleus. INDUCTION: C-fos expression increases upon a variety of stimuli including growth factors cytokines neurotransmitters polypeptide hormones stress and cell injury. SIMILARITY: Belongs to the bZIP family. Fos subfamily SIMILARITY: Contains 1 bZIP domain

UniProt: P01100

Pathways: S100 Proteins