M6PR antibody (Mannose-6-Phosphate Receptor (Cation Dependent)) (Internal Region)

Details for Product anti-M6PR Antibody No. ABIN350472
Antigen
  • CD-MPR
  • MPR 46
  • MPR-46
  • MPR46
  • SMPR
  • Mpr46
  • CDMPR
  • m6pr
  • MGC68896
  • MGC130765
  • zgc:77757
  • wu:fj81h11
  • MGC89423
  • M6PR
  • mprd
  • mannose-6-phosphate receptor, cation dependent
  • mannose-6-phosphate receptor (cation dependent) L homeolog
  • mannose-6-phosphate receptor (cation dependent)
  • mannose-6-phosphate receptor (cation dependent) S homeolog
  • Cation-dependent mannose-6-phosphate receptor
  • M6PR
  • M6pr
  • m6pr.L
  • m6pr
  • m6pr.S
  • Ethha_1678
  • mprd
Epitope
Internal Region
14
5
4
3
2
2
1
1
1
1
1
Reactivity
Mouse (Murine), Rat (Rattus)
66
24
20
4
3
2
2
1
1
Host
Rabbit
54
7
7
3
3
Clonality
Polyclonal
Conjugate
This M6PR antibody is un-conjugated
7
5
5
2
2
2
2
2
2
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
50
32
23
4
4
3
3
3
3
2
1
Options
Immunogen A synthetic peptide from the internal region of mouse MPRD (Cation dependent mannose-6-phosphate receptor) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat.
Isotype IgG
Specificity Specific for MPRD.
Plasmids, Primers & others Plasmids, Primers & others M6PR products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name Mannose 6 Phosphate Receptor (M6PR Antibody Abstract)
Background Function: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
Subunit: Homodimer. Binds GGA1, GGA2 and GGA3.
Subcellular location: Lysosome membrane, Single-pass type I membrane protein. Also known as: CD Man-6-P receptor, CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46, Cation-dependent mannose-6-phosphate receptor, M6pr, 46mpr.
Application Notes Use at a concentration of 10-50 µg/ml.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Ludwig, Ruether, Metzger, Copeland, Jenkins, Lobel, Hoflack: "Gene and pseudogene of the mouse cation-dependent mannose 6-phosphate receptor. Genomic organization, expression, and chromosomal localization." in: The Journal of biological chemistry, Vol. 267, Issue 17, pp. 12211-9, 1992 (PubMed).

Ma, Grubb, Sly: "Cloning, sequencing, and functional characterization of the murine 46-kDa mannose 6-phosphate receptor." in: The Journal of biological chemistry, Vol. 266, Issue 16, pp. 10589-95, 1991 (PubMed).

Szebenyi, Rotwein: "Differential regulation of mannose 6-phosphate receptors and their ligands during the myogenic development of C2 cells." in: The Journal of biological chemistry, Vol. 266, Issue 9, pp. 5534-9, 1991 (PubMed).

Koester, Nagel, von Figura, Pohlmann: "Molecular cloning of the mouse 46-kDa mannose 6-phosphate receptor (MPR 46)." in: Biological chemistry Hoppe-Seyler, Vol. 372, Issue 4, pp. 297-300, 1991 (PubMed).

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