M6PR antibody (N-Term)

Catalog No. ABIN357957

Cited in 1 publication. The Rabbit Polyclonal anti-M6PR antibody (ABIN357957) specifically detects M6PR in IHC (p) and EIA. The antibody is reactive with Human samples.

Quick Overview for M6PR antibody (N-Term) (ABIN357957)

Target: M6PR (Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This M6PR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-M6PR Antibody

Binding Specificity: N-Term

Specificity: This antibody detects M6PR (N-term).

Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human M6PR.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Immunohistochemistry: 1/10-1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

References for anti-M6PR antibody (ABIN357957)

Ohka, Tan, Ishiyama, Ogasawara, Hanasaka, Ishida, Hagiwara, Liu, Chong, Hanaki, Schiavo: "The uncoating of EV71 in mature late endosomes requires CD-M6PR." in: Biology open, Vol. 11, Issue 9, (2022) (PubMed).

Target Details for M6PR

Target: M6PR (Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR))

Alternative Name: M6PR

Background: M6PR is a receptor for mannose-6-phosphate groups on lysosomal enzymes. The receptor forms a homodimer or homotetramer for intracellular targeting of lysosomal enzymes and export of newly synthesized lysosomal enzymes into the cell secretions. The receptor is an integral membrane protein which localizes to the trans-Golgi reticulum, endosomes, and the plasma membrane.Synonyms: 46 kDa mannose 6-phosphate receptor, CD Man-6-P receptor, CD-MPR, Cation-dependent mannose-6-phosphate receptor, MPR46, MPRD

Molecular Weight: 30993 Da

Gene ID: 4074, 9606

UniProt: P20645