SUV39H1 antibody (N-Term)

Catalog No. ABIN356373

This anti-SUV39H1 antibody is a Mouse Monoclonal antibody detecting SUV39H1 in WB and EIA. Suitable for Human and Mouse.

Quick Overview for SUV39H1 antibody (N-Term) (ABIN356373)

Target: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This SUV39H1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 42AT239-96-72

Product Details anti-SUV39H1 Antibody

Binding Specificity: N-Term

Specificity: This antibody is specific to SUV39H1.

Characteristics: Synonyms: SUV39H, Lysine N-methyltransferase 1A, Histone-lysine N-methyltransferase SUV39H1,Histone H3-K9 methyltransferase 1, Position-effect variegation 3-9 homolog, Suppressor ofvariegation 3-9 homolog 1

Purification: Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This antibody was raised using purified recombinant GST fusion protein encodingN-terminal of human SUV39H1.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100-1/500.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for SUV39H1

Target: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Alternative Name: SUV39H1 / KMT1A

Background: Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.Synonyms: Histone H3-K9 methyltransferase 1, Histone-lysine N-methyltransferase SUV39H1, Lysine N-methyltransferase 1A, Position-effect variegation 3-9 homolog, SUV39H, Suppressor of variegation 3-9 homolog 1

Gene ID: 6839

UniProt: O43463