EDAR antibody (Extracellular Domain)

Catalog No. ABIN360882

This anti-EDAR antibody is a Rat Monoclonal antibody detecting EDAR in WB. Suitable for Human and Mouse.

Quick Overview for EDAR antibody (Extracellular Domain) (ABIN360882)

Target: EDAR (Ectodysplasin A Receptor (EDAR))

Reactivity: Human, Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This EDAR antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 9A38

Product Details anti-EDAR Antibody

Binding Specificity: Extracellular Domain

Specificity: This antibody detects EDAR and cross reacts with human EDAR.

Purification: Protein A/G affinity chromatography

Immunogen: Recombinant extracellular domain of EDAR

Isotype: IgG2

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for EDAR

Target: EDAR (Ectodysplasin A Receptor (EDAR))

Alternative Name: EDAR

Background: EDAR (Ectodysplasin A receptor) is a receptor for EDA isoform A1, but not for EDA isoform A2. It has a single transmembrane domain, and shows similarity to 2 separate domains of the tumor necrosis factor (TNF) receptor (TNFR) family. It mediates the activation of NF-kappa-B and JNK and may promote caspase independent cell death. Defects in EDAR are a cause of hypohidrotic ectodermal dysplasia.Synonyms: Anhidrotic ectodysplasin receptor 1, DL, Downless homolog, ED1R, ED3, ED5, EDA-A1 receptor, EDA-A1R, EDA1R, EDA3, Ectodermal dysplasia receptor, Ectodysplasin-A receptor, FLJ94390, HRM1, Tumor necrosis factor receptor superfamily member EDAR

Gene ID: 13608

NCBI Accession: NP_034230

UniProt: Q9R187

Pathways: Tube Formation, Ubiquitin Proteasome Pathway