Peripherin antibody

Catalog No. ABIN361364

The Chicken Polyclonal anti-Peripherin antibody has been validated for WB and IF. It is suitable to detect Peripherin in samples from Rat. There is 1 publication available.

Quick Overview for Peripherin antibody (ABIN361364)

Target: Peripherin (PRPH)

Reactivity: Rat

Host: Chicken

Clonality: Polyclonal

Conjugate: This Peripherin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Peripherin Antibody

Specificity: Specific for the ~57kDa peripherin protein.

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Predicted Reactivity: most mammalian

Purification: Total IgY fraction

Immunogen: Recombinant rat peripherin expressed in and purified from E. coli

Application Details

Application Notes: Recommended Dilution: WB:1:1,000 IF: 1:500 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: total IgY fraction in PBS + 10 mM Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-Peripherin antibody (ABIN361364)

Olson, Abdus-Saboor, Cui, Burdge, Raabe, Ma, Luo: "Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors." in: eLife, Vol. 6, (2018) (PubMed).

Target Details for Peripherin

Target: Peripherin (PRPH)

Alternative Name: PRPH

Background: Peripherin is a ~57kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name. Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in PC12 cells. Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin. In contrast to the neurofilaments, peripherin is strongly up-regulated after nerve injury (1). Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig's disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors (2). Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes (3). Peripherin is not related to peripherin/RDS, a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration. Anti-Peripherin Western blot of rat cerebellar lysate showing specific immunolabeling of the ~ 57k peripherin protein.

Molecular Weight: '57 kDa

Gene ID: 3414

UniProt: P21807