SLC32A1 antibody (N-Term)

Catalog No. ABIN361418

The Rabbit Polyclonal anti-SLC32A1 antibody has been validated for WB. It is suitable to detect SLC32A1 in samples from Rat. There are 6+ publications available.

Quick Overview for SLC32A1 antibody (N-Term) (ABIN361418)

Target: SLC32A1 (Solute Carrier Family 32 (GABA Vesicular Transporter), Member 1 (SLC32A1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC32A1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SLC32A1 Antibody

Binding Specificity: N-Term

Specificity: Specific for the ~53k VGAT protein.

Cross-Reactivity: Chicken, Mouse (Murine), Rat (Rattus)

Predicted Reactivity: bovine, canine, non-human primate

Purification: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Storage: -20 °C

References for anti-SLC32A1 antibody (ABIN361418)

Smith, Jung, Jeon, Kim: "Arid1b haploinsufficiency in parvalbumin- or somatostatin-expressing interneurons leads to distinct ASD-like and ID-like behavior." in: Scientific reports, Vol. 10, Issue 1, pp. 7834, (2020) (PubMed).

Milinkeviciute, Henningfield, Muniak, Chokr, Green, Cramer: "Microglia Regulate Pruning of Specialized Synapses in the Auditory Brainstem." in: Frontiers in neural circuits, Vol. 13, pp. 55, (2020) (PubMed).

Santos, Fuertes, Short, Donohue, Shao, Quintanilla, Malakzadeh, Cohen-Cory: "DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring." in: Neural development, Vol. 13, Issue 1, pp. 22, (2018) (PubMed).

Rotschafer, Cramer: "Developmental Emergence of Phenotypes in the Auditory Brainstem Nuclei of Fmr1 Knockout Mice." in: eNeuro, Vol. 4, Issue 6, (2018) (PubMed).

Rotschafer, Marshak, Cramer: "Deletion of Fmr1 alters function and synaptic inputs in the auditory brainstem." in: PLoS ONE, Vol. 10, Issue 2, pp. e0117266, (2015) (PubMed).

Korn, Koppel, Li, Mehta, Mehta, Seidl, Cramer: "Astrocyte-secreted factors modulate the developmental distribution of inhibitory synapses in nucleus laminaris of the avian auditory brainstem." in: The Journal of comparative neurology, (2011) (PubMed).

Target Details for SLC32A1

Target: SLC32A1 (Solute Carrier Family 32 (GABA Vesicular Transporter), Member 1 (SLC32A1))

Alternative Name: SLC32A1

Background: The Vesicular GABA Amino Acid Transporter (VGAT) is responsible for transport of the inhibitory neurotransmitter into synaptic vesicles(McIntire et al., 1997). The VGAT protein (also known as the Vesicular Inhibitory Amino Aid Transporter or VIAAT) is expressed in synaptic vesicles of both glycine and GABAergic synapses throughout the CNS (Chaudhry et al., 1998). Expression of the VGAT protein changes during development and also in response to patterns of neuronal activity (De et al., 2005). Anti-Vesicular GABA Transporter (VGAT) Western blot of rat hippocampal lysate showing specific immunolabeling of the ~53k VGAT protein.

Molecular Weight: '53 kDa

Gene ID: 83612

UniProt: O35458

Pathways: Proton Transport