SLC6A1 antibody (C-Term)

Catalog No. ABIN361450

This Rabbit Polyclonal antibody specifically detects SLC6A1 in WB and IHC. It exhibits reactivity toward Rat.

Quick Overview for SLC6A1 antibody (C-Term) (ABIN361450)

Target: SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC6A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SLC6A1 Antibody

Binding Specificity: C-Term

Specificity: Specific for the ~67k GAT-1 protein. Immunolabeling is blocked by the peptide used as antigen.

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Purification: Affinity Purified

Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 IHC: 1:100-1:200 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Storage: -20 °C

Target Details for SLC6A1

Target: SLC6A1 (GAT1) (GABA Transporter 1 (GAT1))

Alternative Name: SLC6A1

Background: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003). Anti-GAT1 Western blot of rat hippocampal homogenate showing specific immunolabeling of the~ 67k GAT-1 protein.

Molecular Weight: '67 kDa

Gene ID: 79212

UniProt: P23978