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KCNQ4 antibody (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4) (AA 2-77) Primary Antibody

KCNQ4 Reactivity: Human, Mouse, Rat AA, ICC, IF, IHC, IP, WB Host: Mouse Monoclonal S43-6 unconjugated
Pubmed (3)
Catalog No. ABIN361768
$474.50
Plus shipping costs $45.00
100 μg
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  • Target
    KCNQ4
    Binding Specificity
    AA 2-77
    • 10
    • 7
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Reactivity
    Human, Mouse, Rat
    • 47
    • 21
    • 16
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Host
    Mouse
    Clonality
    Monoclonal
    Conjugate
    This KCNQ4 antibody is un-conjugated
    • 22
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Antibody Array (AA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
    • 39
    • 22
    • 17
    • 13
    • 13
    • 11
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Specificity
    Detects ~77 kDa.
    Purification
    Protein G Purified
    Immunogen
    Fusion protein amino acids 2-77 of human KCNQ4
    Clone
    S43-6
    Isotype
    IgG1
  • Application Notes
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    1 μg/ml of ABIN361768 was sufficient for detection of KCNQ4 in 10 μg of COS-1 cell lysate transiently expressing KCNQ4 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Marchetta, Möhrle, Eckert, Reimann, Wolter, Tolone, Lang, Wolters, Feil, Engel, Paquet-Durand, Kuhn, Knipper, Rüttiger: "Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss." in: Frontiers in aging neuroscience, Vol. 12, pp. 83, 2020 (PubMed).

    Jeng, Ceriani, Hendry, Johnson, Yen, Simmons, Kros, Marcotti: "Hair cell maturation is differentially regulated along the tonotopic axis of the mammalian cochlea." in: The Journal of physiology, Vol. 598, Issue 1, pp. 151-170, 2020 (PubMed).

    Wolter, Möhrle, Schmidt, Pfeiffer, Zelle, Eckert, Krämer, Feil, Pilz, Knipper, Rüttiger: "GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing." in: Frontiers in neural circuits, Vol. 12, pp. 65, 2019 (PubMed).

  • Target
    KCNQ4
    Alternative Name
    KCNQ4 (KCNQ4 Antibody Abstract)
    Synonyms
    KCNQ4, k(v)7.4, kv7.4, DFNA2, DFNA2A, KV7.4, potassium voltage-gated channel subfamily Q member 4, potassium channel, voltage gated KQT-like subfamily Q, member 4, potassium voltage-gated channel, subfamily Q, member 4, KCNQ4, kcnq4, Kcnq4
    Background
    The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability (1), particularly in sensory cells of the cochlea (2). The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug (3).
    Gene ID
    9132
    NCBI Accession
    NP_004691
    UniProt
    P56696
    Pathways
    Sensory Perception of Sound
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