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ICAM1 antibody (Intercellular Adhesion Molecule 1) (pTyr512) Primary Antibody

ICAM1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN362032
$306.90
Plus shipping costs $45.00
100 μL ABIN362032
100 μL ABIN362032
local_shipping Shipping to: United States
Delivery in 6 to 8 Business Days
  • Target
    ICAM1
    Binding Specificity
    • 16
    • 15
    • 14
    • 14
    • 13
    • 9
    • 8
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr512
    Reactivity
    • 274
    • 96
    • 50
    • 12
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Human
    Host
    • 159
    • 151
    • 35
    • 6
    • 3
    • 2
    Rabbit
    Clonality
    • 209
    • 145
    Polyclonal
    Conjugate
    • 170
    • 32
    • 32
    • 26
    • 12
    • 9
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ICAM1 antibody is un-conjugated
    Application
    • 214
    • 161
    • 93
    • 89
    • 72
    • 50
    • 47
    • 45
    • 42
    • 29
    • 27
    • 21
    • 19
    • 11
    • 10
    • 7
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificity
    The antibody detects endogenous level of ICAM-1 only when phosphorylated at tyrosine 512.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogen
    Peptide sequence around phosphorylation site of pTyr512 (K-K-Y (p) -R-L) derived from Human ICAM-1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotype
    IgG
  • Application Notes
    Western blotting: 1:500-1:1000  
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    ICAM1
    Alternative Name
    ICAM-1 (ICAM1 Antibody Abstract)
    Synonyms
    BB2, CD54, P3.58, Icam-1, Ly-47, MALA-2, ICAM, ICAM-1, ICAM1, intercellular adhesion molecule 1, intercellular adhesion molecule-1, ICAM1, Icam1, ICAM-1
    Background
    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin a-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
    Molecular Weight
    92 kDa
    NCBI Accession
    NP_000192
    UniProt
    P05362
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
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