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IRS1 antibody (Insulin Receptor Substrate 1) (AA 637-641) Primary Antibody

IRS1 Reactivity: Human, Mouse, Rat IF, WB Host: Rabbit Polyclonal unconjugated
Pubmed (1)
Catalog No. ABIN362888
$306.90
Plus shipping costs $45.00
100 μL ABIN362888
100 μL ABIN362888
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Delivery in 6 to 8 Business Days
  • Target
    IRS1
    Binding Specificity
    • 31
    • 26
    • 25
    • 22
    • 20
    • 20
    • 19
    • 18
    • 16
    • 16
    • 16
    • 16
    • 16
    • 15
    • 15
    • 13
    • 11
    • 8
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 637-641
    Reactivity
    • 375
    • 303
    • 278
    • 34
    • 27
    • 19
    • 18
    • 18
    • 16
    • 16
    • 13
    • 10
    • 2
    Human, Mouse, Rat
    Host
    • 378
    • 14
    Rabbit
    Clonality
    • 370
    • 22
    Polyclonal
    Conjugate
    • 159
    • 23
    • 19
    • 16
    • 15
    • 15
    • 15
    • 15
    • 15
    • 14
    • 14
    • 14
    • 14
    • 14
    • 14
    • 11
    • 2
    • 1
    • 1
    • 1
    This IRS1 antibody is un-conjugated
    Application
    • 179
    • 146
    • 139
    • 110
    • 105
    • 95
    • 68
    • 54
    • 24
    • 24
    • 19
    • 11
    • 7
    • 2
    • 2
    Immunofluorescence (IF), Western Blotting (WB)
    Specificity
    The antibody detects endogenous level of total IRS-1 protein.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
    Immunogen
    Peptide sequence around AA 637-641 (P-K-S-V-S) derived from Human IRS-1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
    Isotype
    IgG
  • Application Notes
    Western blotting: 1:500-1:1000
    Immunofluorescence: 1:100-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Ekuni, Tomofuji, Irie, Kasuyama, Umakoshi, Azuma, Tamaki, Sanbe, Endo, Yamamoto, Nishida, Morita: "Effects of periodontitis on aortic insulin resistance in an obese rat model." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 90, Issue 3, pp. 348-59, 2010 (PubMed).

  • Target
    IRS1
    Alternative Name
    IRS-1 (IRS1 Antibody Abstract)
    Synonyms
    HIRS-1, G972R, IRS-1, IRS1IRM, irs1, irsu, IRS1, irs-1, irs1-a, insulin receptor substrate 1, insulin receptor substrate 2, insulin receptor substrate 1 S homeolog, IRS1, Irs1, irs2, irs1.S
    Background
    May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit
    Molecular Weight
    180 kDa
    NCBI Accession
    NP_005535
    UniProt
    P35568
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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