Neurofilament (Light Chain) antibody

Catalog No. ABIN363323

The Rabbit Polyclonal anti- antibody has been validated for IHC (p), IF, ICC and WB. It is suitable to detect in samples from Human, Rat and Mouse.

Quick Overview for Neurofilament (Light Chain) antibody (ABIN363323)

Target: Neurofilament (Light Chain)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blotting (WB)

Product Details

Specificity: Reacts with the light neurofilament subunit (~68 kDa)

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Cross-Reactivity (Details): Cross reacts with NF-L from human, cow, pig, mouse, rat and all other mammals. This antibody also recognizes avian NF-L.

Purification: Antiserum

Immunogen: Native NF-L purified from pig spinal cord

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB1:20000 ICC/ IF1:500-1:5000 IHC-P1:5000

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C/-80 °C

Storage Comment: Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.

Target Details

Target: Neurofilament (Light Chain)

Alternative Name: Neurofilament light chain

Background: Belongs to the intermediate filament family. Interacts with RGNEF and with TRIM2. Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F.