PARK7/DJ1 antibody (C-Term)

Catalog No. ABIN363457

This Rabbit Polyclonal antibody specifically detects PARK7/DJ1 in WB, ICC, IF, IP and Func. It exhibits reactivity toward Human and Mouse.

Quick Overview for PARK7/DJ1 antibody (C-Term) (ABIN363457)

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARK7/DJ1 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Functional Studies (Func)

Product Details anti-PARK7/DJ1 Antibody

Binding Specificity: AA 150-189, C-Term

Specificity: Reacts with humanand mouse Protein DJ-1

Cross-Reactivity: Cow (Bovine), Chicken

Cross-Reactivity (Details): May cross react with rat, bovine, Zebra fish, Golden hamster and chicken proteins (100 % sequence homology).

Purification: Antiserum

Immunogen: Synthetic peptide corresponding to the C-terminus (within residues 150-189) of human Park7(DJ-1).

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC1:500 IP1:200 WB1:2 000

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C/-20 °C

Storage Comment: Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Expiry Date: 6 months

Target Details for PARK7/DJ1

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Alternative Name: Protein DJ-1

Background: Park7/DJ-1 is one of several genes thought to cause autosomal-recessive early-onset parkinsonism. Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death.

Gene ID: 11315

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport