CTLA4
Reactivity: Human, Mouse, Rat
FACS, WB, ELISA, IHC (p), IF (p)
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Flow Cytometry: < / = 3 μg/10^6 cells. (Ref.1,2) Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
0.5 mg/mL
Buffer
PBS containing 0.09 % Sodium Azide as preservative.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date
12 months
Target
CTLA4
(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
The lymphocyte surface antigen CD152, also known as CTLA-4, is related to the co-stimulatory molecule CD28, and both molecules share common B7 family counter-receptors. (Ref.1-4) However CD152 is thought to be a negative regulator of T cell activation (Ref.1-3) and may play a role in apoptotic control of T cells. CD152 exists as a 69 kDa homodimer (Ref.1), and is relatively conserved among Humans, Mice and Chickens. (Ref.2)Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4