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CTLA4 Products

(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Categories

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].

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Featured CTLA4 Categories

CTLA4 Antibodies

High quality antibodies with extensive validation data.

CTLA4 ELISA Kits

Reliable ELISA kits for a wide range of species.

CTLA4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CTLA4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, ELISA, WB
Validations
  • (1)
  • (4)
Cat. No. ABIN514751
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (4)
Cat. No. ABIN7149430
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, FACS, ICC, IHC, Neut, WB
Validations
  • (4)
Cat. No. ABIN5611264
Quantity 0.1 mg
Datasheet Datasheet

Recommended CTLA4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966262
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962483
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955276
Quantity 96 tests
Datasheet Datasheet

Recommended CTLA4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (7)
Cat. No. ABIN6961090
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
Cat. No. ABIN7274435
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
Cat. No. ABIN7274437
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our CTLA4 products

Krebs, Trzeciak, Zimmer, Özistanbullu, Mitzel-Rink, Meissner, Grabbe, Loquai, Tuettenberg: "Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma." in: Cancer medicine, (2021) (PubMed).

Bai, Gao, Hu, Liu, Li, Dong, Huang, Zhu, Zhou, Li, Shao: "Self-Assembled Multivalent Aptamer Nanoparticles with Potential CAR-like Characteristics Could Activate T Cells and Inhibit Melanoma Growth." in: Molecular therapy oncolytics, Vol. 17, pp. 9-20, (2020) (PubMed).

Wang, Li, Fan, Wang, Zhang, Zhang, Han, Lv, Liu: "Circulating CTLA-4 levels and CTLA4 polymorphisms associate with disease condition and progression and hepatocellular carcinoma patients' survival in chronic hepatitis B virus infection." in: International immunopharmacology, Vol. 82, pp. 106377, (2020) (PubMed).

Simons, Lim, Carter, Wagner, Wayham, Adler, Johnson: "Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR." in: mAbs, Vol. 12, Issue 1, pp. 1803646, (2020) (PubMed).

Okada, Kajiya, Omata, Matsumoto, Sato, Kobayashi, Nakamura, Kaneko, Nakamura, Koyama, Sudo, Shin, Okamoto, Watanabe, Tachibana, Hirose, Saito, Takai, Matsumoto, Nakamura, Okabe, Miyamoto, Tanaka: "CTLA4-Ig Directly Inhibits Osteoclastogenesis by Interfering With Intracellular Calcium Oscillations in Bone Marrow Macrophages." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).

Ganesan, Moon, Barakat: "Revealing the atomistic details behind the binding of B7-1 to CD28 and CTLA-4: A comprehensive protein-protein modelling study." in: Biochimica et biophysica acta. General subjects, Vol. 1862, Issue 12, pp. 2764-2778, (2019) (PubMed).

Ehlerding, Lee, Jiang, Ferreira, Zahm, Huang, Engle, McNeel, Cai: "Antibody and fragment-based PET imaging of CTLA-4+ T-cells in humanized mouse models." in: American journal of cancer research, Vol. 9, Issue 1, pp. 53-63, (2019) (PubMed).

Galstyan, Markman, Shatalova, Chiechi, Korman, Patil, Klymyshyn, Tourtellotte, Israel, Braubach, Ljubimov, Mashouf, Ramesh, Grodzinski, Penichet, Black, Holler, Sun, Ding, Ljubimov, Ljubimova: "Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy." in: Nature communications, Vol. 10, Issue 1, pp. 3850, (2019) (PubMed).

Gonzalez-Nieto, Castro, Bischof, Shin, Ricciardi, Bailey, Dang, Pedreño-Lopez, Magnani, Ejima, Allison, Gil, Evans, Rakasz, Lifson, Desrosiers, Martins: "Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques." in: PLoS pathogens, Vol. 15, Issue 9, pp. e1008015, (2019) (PubMed).

Ganesan, Ahmed, Okoye, Arutyunova, Babu, Turnbull, Kundu, Shields, Agopsowicz, Xu, Tabana, Srivastava, Zhang, Moon, Belovodskiy, Hena, Kandadai, Hosseini, Hitt, Walker, Smylie, West, Siraki, Lemieux et al.: "Comprehensive in vitro characterization of PD-L1 small molecule inhibitors. ..." in: Scientific reports, Vol. 9, Issue 1, pp. 12392, (2019) (PubMed).

Synonyms and alternative names related to CTLA4

cytotoxic T-lymphocyte associated protein 4 (CTLA4), cytotoxic T-lymphocyte-associated protein 4 (Ctla4), CD, CD152, Cd152, CELIAC3, CTLA-4, Ctla-4, CTLA4, GRD4, GSE, IDDM12, Ly-56, sCTLA4

Protein level used designations for CTLA4

  • cytotoxic T-lymphocyte-associated protein 4 precursor
  • CD152 protein
  • cytotoxic T-lymphocyte protein 4
  • cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM
  • cytotoxic T-lymphocyte-associated protein 4
  • costimulatory molecule B7 receptor
  • cytotoxic T lymphocyte-associated antigen 4
  • CD152 antigen
  • cytotoxic T-lymphocyte-associated antigen 4
  • CD152 isoform
  • celiac disease 3
  • cytotoxic T lymphocyte associated antigen 4 short spliced form
  • cytotoxic T-lymphocyte antigen 4
  • cytotoxic T-lymphocyte-associated serine esterase-4
  • ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
  • soluble form
  • transmembrane form
  • CTLA-4
  • cytotoxic T lymphocyte-associated protein 4
  • costimulatory molecule B7 receptor CD152
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