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Granulin antibody (GRN) (Internal Region) Primary Antibody

GRN Reactivity: Human WB Host: Goat Polyclonal
Catalog No. ABIN375134
$440.00
Plus shipping costs $45.00
0.1 mg
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  • Target
    Binding Specificity
    Internal Region
    Reactivity
    Human
    Host
    Goat
    Clonality
    Polyclonal
    Conjugate
    This Granulin antibody is un-conjugated
    Application
    Western Blotting (WB)
    Specificity
    This antibody recognizes Granulin / GRN.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography
    Immunogen
    Peptide with sequence QSKCLSKENATTD, from the internal region of the protein sequence according to NP_002078.1.
  • Application Notes
    Peptide ELISA: 1/8000. Western Blot: 1 - 3 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Alternative Name
    Granulins (GRN) (GRN Antibody Abstract)
    Background
    Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Tissue specificity: In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney. Involvement in disease: Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485], also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.Synonyms: GRN, Granulins, PEPI, Proepithelin
    Molecular Weight
    63.5 kDa (NP_002078.1)
    Gene ID
    2896, 9606
    UniProt
    P28799
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