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ITGA4 antibody (Integrin alpha 4) (PE) Primary Antibody

ITGA4 Reactivity: Mouse FACS Host: Rat Monoclonal PS-2 PE
Pubmed (1)
Catalog No. ABIN375534
$366.00
Plus shipping costs $45.00
0.2 mg
local_shipping Shipping to: United States
Delivery in 3 to 4 Business Days
  • Target
    ITGA4
    Reactivity
    • 164
    • 137
    • 44
    • 19
    • 11
    • 9
    • 9
    • 8
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 88
    • 83
    • 67
    • 1
    • 1
    Rat
    Clonality
    • 160
    • 80
    • 1
    Monoclonal
    Conjugate
    • 107
    • 27
    • 25
    • 20
    • 9
    • 9
    • 7
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITGA4 antibody is conjugated to PE
    Application
    • 165
    • 54
    • 51
    • 47
    • 39
    • 25
    • 23
    • 13
    • 13
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificity
    Mouse/Human CD49d, Mr 150 kDa
    Characteristics
    Rat Anti-Mouse CD49d-PE
    Purification
    Purified
    Immunogen
    P815 cells
    Clone
    PS-2
    Isotype
    IgG2b
  • Application Notes
    • Applications: FC - Quality tested , IHC-FS - Reported in literature , IP - Reported in literature , Adhesion - Reported in literature , Block - Reported in literature
    • Working Dilutions: Flow Cytometry FITC and BIOT conjugates 2 g/106 cells PE conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
    Sample Volume
    2 mL
    Restrictions
    For Research Use only
  • Concentration
    0.1 mg/mL
    Buffer
    0.1 mg in 1.0 mL or 0.2 mg in 2.0 mL of PBS/Sodium azide and a stabilizing agent
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Do not freeze!
    Protect conjugated products from light.

    Each reagent is stable for the period shown on the bottle label if stored as directed.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C
  • Fistonich, Zehentmeier, Bednarski, Miao, Schjerven, Sleckman, Pereira: "Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development." in: The Journal of experimental medicine, Vol. 215, Issue 10, pp. 2586-2599, 2018 (PubMed).

  • Target
    ITGA4
    Alternative Name
    CD49d (ITGA4 Antibody Abstract)
    Synonyms
    CD49D, IA4, LOC100219853, integrin subunit alpha 4, integrin alpha 4, integrin subunit alpha 4 S homeolog, ITGA4, Itga4, itga4.S
    Background
    VLA-4 belongs to the β 1 -integrin family, which functions both as cell-matrix and cell-cell receptors. As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1. In addition to CD44/pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1. CD49d/VLA-4 is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive.
    Pathways
    Integrin Complex
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