MLH1 antibody (MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli))

Details for Product anti-MLH1 Antibody No. ABIN379237
Antigen
  • CG11482
  • Dmel\\CG11482
  • dmlh-1
  • dmlh1
  • zgc:66301
  • MLH1
  • LOC100232198
  • 1110035C23Rik
  • AI317206
  • AI325952
  • AI561766
  • COCA2
  • FCC2
  • HNPCC
  • HNPCC2
  • hMLH1
  • mutL homolog 1
  • CG11482 gene product from transcript CG11482-RB
  • mutL homolog 1 S homeolog
  • mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
  • DNA mismatch repair protein Mlh1
  • MLH1
  • Mlh1
  • mlh1.S
  • mlh1
  • LOC588545
Reactivity
Hamster, Human, Rat (Rattus)
150
60
59
10
4
3
2
2
2
2
2
2
2
1
1
1
Host
Mouse
103
49
Clonality (Clone)
Monoclonal ()
Conjugate
This MLH1 antibody is un-conjugated
5
4
4
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
112
61
33
30
25
23
13
11
7
6
4
3
2
2
1
Options
Immunogen Full length recombinant MLH.

Type of Immunogen: Recombinant protein
Clone G168-15
Isotype IgG1
Specificity The G168-15 antibody recognizes the human and mouse MLH1 (80-85  kDa. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair. cross reacts with human, hamster and rat
Plasmids, Primers & others Plasmids, Primers & others MLH1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name MLH1 (MLH1 Antibody Abstract)
Background Name/Gene ID: MLH1

Synonyms: MLH1, COCA2, FCC2, HMLH1, HNPCC, HNPCC2, MutL protein homolog 1
Gene ID 4292
Pathways DNA Damage Repair, Production of Molecular Mediator of Immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Supplied as a liquid containing sodium azide as a preservative
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze.
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