BOK antibody (AA 60-90)

Catalog No. ABIN388103

The Rabbit Polyclonal anti-BOK antibody has been validated for WB and IHC (p). It is suitable to detect BOK in samples from Human. There are 3+ publications available.

Quick Overview for BOK antibody (AA 60-90) (ABIN388103)

Target: BOK (BCL2-Related Ovarian Killer (BOK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BOK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-BOK Antibody

Binding Specificity: AA 60-90

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-BOK antibody (ABIN388103)

Kurata, Yanagisawa, Ohira, Kitagawa, Nakagawara, Kamijo: "Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells." in: Oncogene, Vol. 27, Issue 6, pp. 741-54, (2008) (PubMed).

Gao, Fu, Dürrenberger, De Geyter, Zhang: "Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3." in: Cellular and molecular life sciences : CMLS, Vol. 62, Issue 9, pp. 1015-24, (2005) (PubMed).

Yakovlev, Di Giovanni, Wang, Liu, Stoica, Faden: "BOK and NOXA are essential mediators of p53-dependent apoptosis." in: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28367-74, (2004) (PubMed).

Target Details for BOK

Target: BOK (BCL2-Related Ovarian Killer (BOK))

Alternative Name: Bok

Background: Bok belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains all four BCL-2 like domains (BH1, 2, 3 and 4) and is a pro-apoptotic BCL-2 protein identified in the ovary.

Gene ID: 666

NCBI Accession: NP_115904

UniProt: Q9UL32

Pathways: Positive Regulation of Endopeptidase Activity