YES1/SRC (pTyr530) antibody

Catalog No. ABIN389661

Cited in 2+ publications. This anti-YES1/SRC antibody is a Rabbit Polyclonal antibody detecting YES1/SRC in DB and IHC (p). Suitable for Human.

Quick Overview for YES1/SRC (pTyr530) antibody (ABIN389661)

Target: YES1/SRC

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB05974

Product Details

Binding Specificity: pTyr530

Predicted Reactivity: C, Zf, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SRC Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y530 of human SRC.

Isotype: Ig Fraction

Application Details

Application Notes: IHC-P: 1:50~100. DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Expiry Date: 6 months

References

Miller, Morton, Pinese, Saturno, Jamieson, McGhee, Timpson, Leach, McGarry, Shanks, Bailey, Chang, Oien, Karim, Au, Steele, Carter, McKay, Anderson, Evans, Marais, Springer, Biankin, Erler, Sansom: "Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy." in: EMBO molecular medicine, Vol. 7, Issue 8, pp. 1063-76, (2015) (PubMed).

Varrin-Doyer, Vincent, Cavagna, Auvergnon, Noraz, Rogemond, Honnorat, Moradi-Améli, Giraudon: "Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration." in: The Journal of biological chemistry, Vol. 284, Issue 19, pp. 13265-76, (2009) (PubMed).

Target Details

Target: YES1/SRC

Background: This protein has tyrosine kinase activity and belongs to the src family of proteins. The YES1 gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene.

Gene ID: 6714

NCBI Accession: NP_005408, NP_938033

UniProt: P12931, P07947