MLLT1 antibody (C-Term)

Catalog No. ABIN390126

Cited in 1 publication. The Rabbit Polyclonal anti-MLLT1 antibody (Clone RB1927-1928) (ABIN390126) specifically detects MLLT1 in WB. The antibody is reactive with Human samples.

Quick Overview for MLLT1 antibody (C-Term) (ABIN390126)

Target: MLLT1 (MLLT1, super elongation complex subunit (MLLT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLLT1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB1927-1928

Product Details anti-MLLT1 Antibody

Binding Specificity: AA 523-552, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MLLT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 523-552 amino acids from the C-terminal region of human MLLT1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:2000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MLLT1 antibody (ABIN390126)

Bitoun, Oliver, Davies: "The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling." in: Human molecular genetics, Vol. 16, Issue 1, pp. 92-106, (2007) (PubMed).

Target Details for MLLT1

Target: MLLT1 (MLLT1, super elongation complex subunit (MLLT1))

Alternative Name: MLLT1

Background: Chromosome band 11q23 is the site of translocations in myeloid and lymphoid acute leukemias, pediatric leukemias, and treatment-induced secondary acute myelogenous leukemia. The translocation breakpoints cluster in a restricted region of the HRX gene resulting in chimeric genes that encode an N-terminal portion of Hrx fused to various partner proteins. Myeloid/lymphoid or mixed-lineage leukemia translocated to 1 (MLLT1) is a nuclear protein with transcriptional transactivation properties that is fused to Hrx in t(11,19) leukemias. The minimal MLLT1 sequence required for transcription activation was narrowed to the C-terminal 90 amino acids.

Molecular Weight: 62056

Gene ID: 4298

NCBI Accession: NP_005925

UniProt: Q03111