PARP12 antibody (C-Term)

Catalog No. ABIN390267

This anti-PARP12 antibody is a Rabbit Polyclonal antibody detecting PARP12 in WB. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for PARP12 antibody (C-Term) (ABIN390267)

Target: PARP12 (Poly (ADP-Ribose) Polymerase Family, Member 12 (PARP12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP12 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB14194

Product Details anti-PARP12 Antibody

Binding Specificity: AA 454-483, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Parp12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-483 amino acids from the C-terminal region of mouse Parp12.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-PARP12 antibody (ABIN390267)

Carter, Sykes, Lanning: "Scarless fetal mouse wound healing may initiate apoptosis through caspase 7 and cleavage of PARP." in: The Journal of surgical research, Vol. 156, Issue 1, pp. 74-9, (2009) (PubMed).

Target Details for PARP12

Target: PARP12 (Poly (ADP-Ribose) Polymerase Family, Member 12 (PARP12))

Alternative Name: Parp12

Background: Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.

Molecular Weight: 79917

Gene ID: 243771

NCBI Accession: NP_766481

UniProt: Q8BZ20