SNCAIP antibody (C-Term)

Catalog No. ABIN390382

This Rabbit Polyclonal antibody specifically detects SNCAIP in WB. It exhibits reactivity toward Human.

Quick Overview for SNCAIP antibody (C-Term) (ABIN390382)

Target: SNCAIP (Synuclein, alpha Interacting Protein (SNCAIP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNCAIP antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB7392

Product Details anti-SNCAIP Antibody

Binding Specificity: AA 593-622, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Synphilin-1 (SNCAIP) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 593-622 amino acids from the C-terminal region of human Synphilin-1 (SNCAIP).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for SNCAIP

Target: SNCAIP (Synuclein, alpha Interacting Protein (SNCAIP))

Alternative Name: Synphilin-1 (SNCAIP)

Background: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease

Molecular Weight: 100409

Gene ID: 9627

NCBI Accession: NP_001229864, NP_005451

UniProt: Q9Y6H5