B-Cell Linker antibody (AA 150-178)

Catalog No. ABIN390395

The Rabbit Polyclonal anti-B-Cell Linker antibody has been validated for WB, FACS and IHC (p). It is suitable to detect B-Cell Linker in samples from Human.

Quick Overview for B-Cell Linker antibody (AA 150-178) (ABIN390395)

Target: B-Cell Linker (BLNK)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This B-Cell Linker antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB18883

Product Details anti-B-Cell Linker Antibody

Binding Specificity: AA 150-178

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BLNK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 150-178 amino acids from the Central region of human BLNK.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for B-Cell Linker

Target: B-Cell Linker (BLNK)

Alternative Name: BLNK

Background: BLNK is a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in its gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia.

Molecular Weight: 50466

Gene ID: 29760

NCBI Accession: NP_001107566, NP_001245369, NP_037446

UniProt: Q8WV28

Pathways: BCR Signaling