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EPHA1 antibody (Ephrin Type A Receptor 1) (AA 913-943) Primary Antibody

EPHA1 Reactivity: Human IHC (p), WB Host: Rabbit Polyclonal RB1578 unconjugated
Pubmed (3)
Catalog No. ABIN391884
$423.50
Plus shipping costs $45.00
400 μL ABIN391884
400 μL ABIN391884
local_shipping Shipping to: United States
Delivery in 10 to 11 Business Days
  • Target
    EPHA1
    Binding Specificity
    • 12
    • 12
    • 10
    • 10
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 913-943, C-Term
    Reactivity
    • 111
    • 67
    • 18
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    Human
    Host
    • 125
    • 7
    Rabbit
    Clonality
    • 125
    • 8
    Polyclonal
    Conjugate
    • 56
    • 12
    • 9
    • 8
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This EPHA1 antibody is un-conjugated
    Application
    • 95
    • 74
    • 48
    • 21
    • 13
    • 12
    • 7
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This EphA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 913-943 amino acids from the C-terminal region of human EphA1.
    Clone
    RB1578
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Wang, Hu, Tian, Zhou, Zhou, Wang: "Expression of EphA2 protein is positively associated with age, tumor size and Fuhrman nuclear grade in clear cell renal cell carcinomas." in: International journal of clinical and experimental pathology, Vol. 8, Issue 10, pp. 13374-80, 2016 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

    Wang, Liu, Cao, Zhang, Xu, Xu, Wang: "Expression of the EphA1 protein is associated with Fuhrman nuclear grade in clear cell renal cell carcinomas." in: International journal of clinical and experimental pathology, Vol. 8, Issue 6, pp. 6821-7, 2015 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

    Dong, Wang, Sheng, Li, Ma, Wang, Zhang, Lu, Hu, Sugimura, Zhou: "Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 1, pp. 151-60, 2008 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

  • Target
    EPHA1
    Alternative Name
    EphA1 (EPHA1 Antibody Abstract)
    Synonyms
    EPH, EPHT, EPHT1, 5730453L17Rik, AL033318, Eph, Esk, EPHA9, EPH receptor A1, Eph receptor A1, EPHA1, Epha1
    Background
    Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
    Molecular Weight
    108127
    Gene ID
    2041
    NCBI Accession
    NP_005223
    UniProt
    P21709
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