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ROR2 antibody (Receptor Tyrosine Kinase-Like Orphan Receptor 2) Primary Antibody

ROR2 Reactivity: Human IHC (p), WB Host: Rabbit Polyclonal RB16733 unconjugated
Pubmed (2)
Catalog No. ABIN392046
$423.50
Plus shipping costs $45.00
400 μL ABIN392046
400 μL ABIN392046
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  • Target
    ROR2
    Reactivity
    Human
    • 92
    • 27
    • 25
    • 2
    • 2
    • 2
    • 1
    Host
    Rabbit
    Clonality
    Polyclonal
    Conjugate
    This ROR2 antibody is un-conjugated
    • 38
    • 9
    • 7
    • 6
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Application
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    • 72
    • 53
    • 49
    • 21
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    Specificity
    This ROR2 antibody is generated from rabbits immunized with a recombinant protein of human ROR2.
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This ROR2 antibody is generated from rabbits immunized with a recombinant protein of human ROR2.
    Clone
    RB16733
    Isotype
    Ig Fraction
  • Application Notes
    WB = 1:1000, IHC (p) = 1:10-50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    2 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Zhu, Yang, Liu, Zou, Yuan, Hu et al.: "Association between Wnt inhibitory factor 1 and receptor tyrosine kinase-like orphan receptor 2 protein expression and the clinical pathological significance in benign and malignant pancreatic ..." in: Oncology letters, Vol. 13, Issue 4, pp. 2244-2252, 2017 (PubMed). Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

    Cerpa, Latorre-Esteves, Barria: "RoR2 functions as a noncanonical Wnt receptor that regulates NMDAR-mediated synaptic transmission." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 15, pp. 4797-802, 2015 (PubMed). Method employed by authors: Immunofluorescence (IF)

  • Target
    ROR2
    Alternative Name
    ROR2 (ROR2 Antibody Abstract)
    Synonyms
    BDB, BDB1, NTRKR2, Ntrkr2, mRor2, ROR2, bdb, bdb1, Xror2, ntrkr2, MGC97773, LOC100219935, ror2, xror2, receptor tyrosine kinase like orphan receptor 2, receptor tyrosine kinase-like orphan receptor 2, receptor tyrosine kinase like orphan receptor 2 L homeolog, ROR2, Ror2, ror2, ror2.L
    Background
    ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.
    Synonyms: Tyrosine-protein kinase transmembrane receptor ROR2, Neurotrophic tyrosine kinase, receptor-related 2 NTRKR2
    Molecular Weight
    104726 DA
    Gene ID
    4920
    NCBI Accession
    NP_004551
    Pathways
    RTK Signaling, WNT Signaling
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