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KIT antibody (Mast/stem Cell Growth Factor Receptor) (AA 934-938) Primary Antibody

KIT Reactivity: Human IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN401647
$350.90
Plus shipping costs $45.00
50 μL ABIN401647
50 μL ABIN401647
local_shipping Shipping to: United States
Available
  • Target
    KIT
    Binding Specificity
    • 66
    • 65
    • 42
    • 30
    • 24
    • 24
    • 24
    • 20
    • 19
    • 18
    • 17
    • 16
    • 16
    • 16
    • 16
    • 16
    • 15
    • 15
    • 12
    • 12
    • 12
    • 11
    • 10
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 934-938
    Reactivity
    • 773
    • 246
    • 72
    • 31
    • 30
    • 28
    • 16
    • 13
    • 8
    • 5
    • 4
    • 2
    • 2
    • 1
    Human
    Host
    • 668
    • 144
    • 49
    • 7
    • 2
    • 2
    Rabbit
    Clonality
    • 662
    • 211
    Polyclonal
    Conjugate
    • 271
    • 86
    • 81
    • 81
    • 64
    • 64
    • 51
    • 16
    • 14
    • 14
    • 13
    • 13
    • 13
    • 12
    • 10
    • 10
    • 10
    • 10
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This KIT antibody is un-conjugated
    Application
    • 462
    • 376
    • 324
    • 174
    • 91
    • 83
    • 81
    • 74
    • 59
    • 48
    • 39
    • 28
    • 16
    • 8
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    C-kit Antibody detects endogenous levels of total c-kit protein.
    Purification
    Affinity Chromatography using epitope-specific peptide
    Immunogen
    peptide sequence around amino acids 934~938 (H-I-Y-S-N) derived from Human c-kit.
  • Application Notes
    Immunohistochemistry: 1/50 - 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
  • Target
    KIT
    Alternative Name
    CD117 / C-Kit (KIT Antibody Abstract)
    Synonyms
    C-Kit, CD117, PBT, SCFR, Bs, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, W, c-KIT, c-kit, MGF, KIT, C-KIT, kit, receptor, sparse, Xkl-1, kit-a, kit-b, kl1-A, krk1, pbt, scfr, KIT proto-oncogene receptor tyrosine kinase, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a, KIT proto-oncogene receptor tyrosine kinase S homeolog, KIT, Kit, kita, kit, kit.S
    Background
    C-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR
    Gene ID
    3815
    NCBI Accession
    NP_000213
    UniProt
    P10721
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
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