PSMA7 antibody (Middle Region)

Catalog No. ABIN453792

This anti-PSMA7 antibody is a Rabbit Polyclonal antibody detecting PSMA7 in WB and EIA. Suitable for Human and Mouse.

Quick Overview for PSMA7 antibody (Middle Region) (ABIN453792)

Target: PSMA7 (Proteasome Subunit alpha 7 (PSMA7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMA7 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-PSMA7 Antibody

Binding Specificity: Middle Region

Specificity: This antibody reacts to PSMA7.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide selected from the Center region of human PSMA7

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PSMA7

Target: PSMA7 (Proteasome Subunit alpha 7 (PSMA7))

Alternative Name: PSMA7

Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA7 is a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension.Synonyms: HSPC, Proteasome subunit RC6-1, Proteasome subunit XAPC7, Proteasome subunit alpha type-7

Gene ID: 5688

NCBI Accession: NP_002783

UniProt: O14818

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA