Smith Antigen antibody
The Human Polyclonal anti- antibody has been validated for ID and EIA. It is suitable to detect in samples from Human.
Quick Overview for Smith Antigen antibody (ABIN453884)
Target
Smith Antigen
Reactivity
Human
Host
Human
Clonality
Polyclonal
Conjugate
Un-conjugated
Application
Immunodiffusion (ID), Enzyme Immunoassay (EIA)
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Purification
- Single donor human plasma is delipidized and defibrinated. An immunoglobulin fraction is then precipitated and collected.
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Application Notes
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Immunodiffusion. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Format
- Liquid
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Reconstitution
- Restore with 2 mL deionized water
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Buffer
- 0.01 M Phosphate, 0.11 M Sodium chloride containing 0.02 % Sodium Azide
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Preservative
- Sodium azide
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Precaution of Use
- Source material supplied to your facility has been tested for the detection of HIV antibody, Hepatitis B surface antigen, antibody to Hepatitis C, HIV 1 antigen(s), antibody to HTLV - I/II, and syphilis with FDA approved test kits. All units were found to be non- reactive/negative for these tests. Nevertheless, all products from human sources should be handled as potentially infectious.
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Handling Advice
- Avoid repeated freezing and thawing.
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Storage
- -20 °C
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- Smith Antigen
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Alternative Name
- Sm / Smith Antigen
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Background
- The sm (Smith) is an autoantigen on a series of particles composed of RNA and protein. Unlike RNP, the sm antigen is resistant to RNase, but partially sensitive to trypsin. It is involved in the pathogenesis of Systemic lupus erythematosus (SLE). Antibodies to sm are found in 20-30 % of patients with SLE. This antibody recognizes cross-reactive epitopes on the B'/B and D polypeptides of Sm. It precipitates the small nuclear RNAs U1, U2, U4, U5, and U6 providing direct evidence that the Sm antigen resides on all these RNA-protein complexes.Synonyms: Human Autoantigens
Target
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