Cathepsin G antibody (AA 25-252)

Catalog No. ABIN4886550

Product Details anti-Cathepsin G Antibody

Target: Cathepsin G (CTSG)

Binding Specificity: AA 25-252

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin G antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purpose: Anti-Cathepsin G/CTSG Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Cathepsin G/CTSG Antibody Picoband® (ABIN4886550). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Cathepsin G recombinant protein (Position: R25-E252). Human Cathepsin G shares 69.7% amino acid (aa) sequence identity with mouse Cathepsin G.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human
1. "Entrez Gene: CTSG cathepsin G". 2. Grisolano, J. L., Sclar, G. M., Ley, T. J. Early myeloid cell-specific expression of the human Casthepsin G gene in transgenic mice. Proc. Nat. Acad. Sci. 91: 8989-8993, 1994.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for Cathepsin G

Target: Cathepsin G (CTSG)

Alternative Name: CTSG (CTSG Products)

Background:

Synonyms: Cathepsin G,CG,3.4.21.20,CTSG,

Tissue Specificity: B-cells and in primary carcinomas.

Background: Cathepsin G is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. This gene is mapped to 14q12. In transgenic mice, it was found that human Cathepsin G gene was expressed in early myeloid precursors in a manner coordinate with the expression of the endogenous murine gene in the bone marrow and spleen. The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation.

Molecular Weight: 35 kDa

Gene ID: 1511

UniProt: P08311

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones