Vip antibody (Middle Region)

Catalog No. ABIN4886760

This anti-Vip antibody is a Rabbit Polyclonal antibody detecting Vip in IHC and IF. Suitable for Human, Rat and Mouse. This Primary Antibody has been cited in 1 publication.

Quick Overview for Vip antibody (Middle Region) (ABIN4886760)

Target: Vip (Vasoactive Intestinal Peptide (Vip))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Vip antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Vip Antibody

Binding Specificity: AA 81-107, Middle Region

Purpose: Anti-VIP peptides VIP Antibody

Sequence: HADGVFTSDF SKLLGQLSAK KYLESLM

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-VIP peptides VIP Antibody (ABIN4886760). Tested in IF, IHC applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human VIP, different from the related mouse and rat sequences by four amino acids.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunofluorescence, 5 μg/mL, Rat
1. Fahrenkrug J, Emson PC (Sep 1982). "Vasoactive intestinal polypeptide: functional aspects". British Medical Bulletin 38 (3): 265-70. 2. Linder S, Barkhem T, Norberg A, Persson H, Schalling M, Hökfelt T, Magnusson G (Jan 1987). "Structure and expression of the gene encoding the vasoactive intestinal peptide precursor". Proceedings of the National Academy of Sciences of the United States of America 84 (2): 605-9. 3. Said SI (Apr 1986). "Vasoactive intestinal peptide". Journal of Endocrinological Investigation 9 (2): 191-200.

Comment:

Antibody can be supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

References for anti-Vip antibody (ABIN4886760)

Huang, Zhu, Zhang, Zhu, Liu, Zhu, Wang, Li, Yang, Dong, Liu, Chen, Zhang, Yang, Deng, Fan, Wang, Liu, Ma, Fu, Wu: "S100+ cells: a new neuro-immune cross-talkers in lymph organs." in: Scientific reports, Vol. 3, pp. 1114, (2013) (PubMed).

Target Details for Vip

Target: Vip (Vasoactive Intestinal Peptide (Vip))

Alternative Name: VIP

Background:

Synonyms: VIP peptides,Intestinal peptide PHV-42,Peptide histidine valine 42,Intestinal peptide PHM-27,Peptide histidine methioninamide 27,Vasoactive intestinal peptide,VIP,Vasoactive intestinal polypeptide,VIP,

Tissue Specificity: Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.

Background: Vasoactive intestinal peptide, also known as PHM27 or VIP, is a peptide hormone containing 28 amino acid residues. This gene is mapped to 6q25. The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.

Molecular Weight: 26 kDa

Gene ID: 7432

UniProt: P01282

Pathways: Hormone Activity, cAMP Metabolic Process