Porphyromonas Gingivalis antibody

Catalog No. ABIN4888519

Product Details

Target: Porphyromonas Gingivalis

Reactivity: Porphyromonas gingivalis

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Confocal Laser Scanning Microscopy (CLSM), ELISA, Flow Cytometry (FACS)

Specificity: Porphyromonas gingivalis, The antibody anti P ginigivalis was found to be reactive toward S. oralis ATCC9811 and F. nucleatum ATCC 25586 until 1:200v/v dilution, while crossreactivity toward S. mutans ATCC 25175 only at 1:50v/v dilution

Characteristics: Porphyromonas gingivalis is an anaerobic, Gram-negative bacterium that can be found within the mouth of an individual. This bacterium is the principal source of periodontal disease. It has been found that in addition to causing human infections, this bacterium also causes much of the antibiotic resistance problems found today. The way which it operates is very unique, since it is a Gram-negative bacteria, it can attach to the subgingival coating of the tooth, and it will substitute the Gram-positive bacteria that is originally there with its own thus causing an inflammation which will disengage the gums from the teeth. The bacteria, P. gingivalis, in addition to others causes gingivitis as well as periodontis. Gingivitis is "A disorder involving inflammation of the gums, may affect surrounding and supporting structures of the teeth." Periodontis is "inflammatory reaction of the tissues surrounding a tooth (periodontium), usually resulting from the extension of gingival inflammation into the periodontium." When a gathering of Gram-negative, anaerobic bacteria is observed on the gums, it develops a biofilm called plaque on the tooth [1-2].Thus P. gingivalis expresses proteolytic enzymes which regulate the protein function in the body. These enzymes are usually utilized for Cysteine and Arginine metabolism. However, here they affect the link between the tooth and the bone, thus ultimately separating the two from one another, which causes the taking apart of the tooth from jaw [3]. In the last few years it is intensively investigate the role of P. gingivalis in atherosclerosis development and in promoting or inflicting different cancers

Purification: Polyclonal immunoglobulins purified by protein A affinity chromatography

Immunogen: P. gingivalis ATCC 33277 1010 cells inactivated in glutaraldehyde 2.5%v/v

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in 100 mM sodium citrate, 50 mM Tris and 0.05 % v/v glycerol. Neutral pH.

Storage: 4 °C

References

Manti, Ciandrini, Campana, Dominici, Ciacci, Federici, Sisti, Rocchi, Papa, Baffone: "A dual-species microbial model for studying the dynamics between oral streptococci and periodontal pathogens during biofilm development on titanium surfaces by flow cytometry." in: Research in microbiology, Vol. 167, Issue 5, pp. 393-402, (2017) (PubMed).

Target Details

Target: Porphyromonas Gingivalis

Target Type: Species