Dityrosine antibody

Catalog No. ABIN492669

This anti-Dityrosine antibody is a Mouse Monoclonal antibody detecting Dityrosine in WB, EIA and IHC (p). Suitable for . This Primary Antibody has been cited in 1 publication.

Quick Overview for Dityrosine antibody (ABIN492669)

Target: Dityrosine (DT)

Host: Mouse

Clonality: Monoclonal

Conjugate: This Dityrosine antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1C3

Product Details anti-Dityrosine Antibody

Purification: Protein A Chromatography

Immunogen: 3-(p-hydroxyphenyl) propionic acid dimer KLH-conjugated

Isotype: IgG2a

Application Details

Application Notes: ELISA (Ref.1,2)Western bLot (Ref.3,5)Immunohistochemistry on Paraffin Sections (Ref.4).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in 200 μL aqua bidest to 0.1 mg/mL

Storage: -20 °C

Storage Comment: Store the antibody at -20 °CAfter reconstitution, store as frozen aliquotsAvoid repeated freezing and thawingShelf life: One year from despatch.

Expiry Date: 12 months

References for anti-Dityrosine antibody (ABIN492669)

Li, Shi, Ding, Ran, Le: "Dietary oxidized tyrosine (O-Tyr) stimulates TGF-β1-induced extracellular matrix production via the JNK/p38 signaling pathway in rat kidneys." in: Amino acids, Vol. 49, Issue 2, pp. 241-260, (2018) (PubMed).

Target Details for Dityrosine

Target: Dityrosine (DT)

Alternative Name: Dityrosine / DT

Target Type: Dipeptide

Background: Tyrosine is one of the major targets of protein oxidation, and until today various tyrosine derivatives such as nitrotyrosine, dityrosine and halogenated tyrosine depending on the type of free radicals. DT is a tyrosine dimer derived from tyrosyl radicals which is formed by reactive oxygen species (ROS), metal-catalyzed oxidation, ultraviolet irradiation, and peroxidases. DT have been found in atherosclerotic lesions, and lipofuscin of pyramidal neurons of aged human brains. Dityrosine is one of the specific biomarkers for protein oxidation.