Desmoglein 1 antibody (Internal Region)

Catalog No. ABIN4949605

The Mouse Monoclonal anti-Desmoglein 1 antibody has been validated for WB, IF, FACS and IP. It is suitable to detect Desmoglein 1 in samples from Human.

Quick Overview for Desmoglein 1 antibody (Internal Region) (ABIN4949605)

Target: Desmoglein 1 (DSG1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Desmoglein 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: 27B2

Product Details anti-Desmoglein 1 Antibody

Binding Specificity: Internal Region

Purification: Protein G affinity chromatography

Immunogen: A recombinant protein corresponding to the intracellular domain of human Desmoglein 1 was used as the immunogen for the DSG1 antibody.

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal dilution of the DSG1 antibody should be determined by the researcher.\. FACS: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 1-2 μg/mL,WB: 0.5-1 μg/mL,Immunoprecipitation: suitable

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the DSG1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Target Details for Desmoglein 1

Target: Desmoglein 1 (DSG1)

Alternative Name: Desmoglein 1 / DSG1

Background: Desmoglein 1 (DSG1) is a member of the desmosomal cadherin family. Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms. Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

Pathways: Cell-Cell Junction Organization