L-Selectin antibody (AA 39-372)

Catalog No. ABIN4950499

The Rabbit Polyclonal anti-L-Selectin antibody is suitable to detect L-Selectin in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and IHC (p).

Quick Overview for L-Selectin antibody (AA 39-372) (ABIN4950499)

Target: L-Selectin (SELL) (Selectin L (SELL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This L-Selectin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-L-Selectin Antibody

Binding Specificity: AA 39-372

Purification: Antigen affinity

Immunogen: Amino acids 39-372 of human CD62L were used as the immunogen for the CD62L antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CD62L antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,ELISA : 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the CD62L antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for L-Selectin

Target: L-Selectin (SELL) (Selectin L (SELL))

Alternative Name: L-Selectin (CD62L)

Background: CD62L, also known as L-selectin, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups. It is cleaved by ADAM17. SELL (L-selectin) is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins. L-selectin acts as a homing receptor for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point.

UniProt: P14151