SIRT6 antibody

Catalog No. ABIN4953432

This Mouse Monoclonal antibody specifically detects SIRT6 in WB, IP, ICC and IF. It exhibits reactivity toward Human, Mouse, Rat and Primate.

Quick Overview for SIRT6 antibody (ABIN4953432)

Target: SIRT6 (Sirtuin 6 (SIRT6))

Reactivity: Human, Mouse, Rat, Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIRT6 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: 6C9-D10-D3

Product Details anti-SIRT6 Antibody

Purification: Protein G affinity

Immunogen: A human recombinant protein was used as the immunogen for this SIRT6 antibody.

Isotype: IgG1

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the SIRT6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:500,ICC/IF: 1:100,Immunoprecipitation: suitable

Restrictions: For Research Use only

Handling

Buffer: Antibody in PBS with 50 % Glycerol and 0.03 % ProClin 300

Storage: -20 °C

Storage Comment: Store the SIRT6 antibody at -20°C.

Target Details for SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Alternative Name: SIRT6

Background: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. [UniProt]

UniProt: Q8N6T7