ABCB7 antibody (AA 718-746)

Catalog No. ABIN3030053

The Rabbit Polyclonal anti-ABCB7 antibody has been validated for ELISA, WB and IHC. It is suitable to detect ABCB7 in samples from Human.

Quick Overview for ABCB7 antibody (AA 718-746) (ABIN3030053)

Target: ABCB7 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCB7 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ABCB7 Antibody

Binding Specificity: AA 718-746

Cross-Reactivity (Details): Expected species reactivity: Mouse, Rat

Purification: Purified

Immunogen: A portion of amino acids 718-746 from the human protein was used as the immunogen for this ABCB7 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the ABCB7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the ABCB7 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for ABCB7

Target: ABCB7 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 (ABCB7))

Alternative Name: ABCB7

Background: The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.

UniProt: O75027

Pathways: Transition Metal Ion Homeostasis