CD40 antibody (AA 247-276)

Catalog No. ABIN3030395

The Rabbit Polyclonal anti-CD40 antibody has been validated for WB and ELISA. It is suitable to detect CD40 in samples from Human.

Quick Overview for CD40 antibody (AA 247-276) (ABIN3030395)

Target: CD40

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD40 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CD40 Antibody

Binding Specificity: AA 247-276

Cross-Reactivity (Details): Expected species reactivity: Mouse, Pig

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 247-276 from the human protein was used as the immunogen for this CD40 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the CD40 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CD40 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for CD40

Target: CD40

Alternative Name: CD40

Background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

UniProt: P25942

Pathways: NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints