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HES1 antibody (C-Term)

HES1 Reactivity: Mouse ELISA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031194
$578.58
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  • Target See all HES1 Antibodies
    HES1 (Hes Family bHLH Transcription Factor 1 (HES1))
    Binding Specificity
    • 16
    • 12
    • 9
    • 9
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 5205-239, C-Term
    Reactivity
    • 85
    • 52
    • 45
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Mouse
    Host
    • 75
    • 17
    • 1
    • 1
    Rabbit
    Clonality
    • 68
    • 26
    Polyclonal
    Conjugate
    • 53
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This HES1 antibody is un-conjugated
    Application
    • 62
    • 36
    • 20
    • 16
    • 14
    • 13
    • 10
    • 7
    • 5
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Cross-Reactivity (Details)
    Expected species reactivity: Human, Rat
    Purification
    Antigen affinity purified
    Immunogen
    This mouse Hes1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 205-239 amino acids from the C-terminal region of mouse Hes1.
    Isotype
    Ig Fraction
  • Application Notes
    Titration of the Hes1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the Hes1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    HES1 (Hes Family bHLH Transcription Factor 1 (HES1))
    Alternative Name
    Hes1 (HES1 Products)
    Synonyms
    HES-1 antibody, HHL antibody, HRY antibody, bHLHb39 antibody, Hry antibody, HAIRY1 antibody, c-hairy1A antibody, Xhairy-1 antibody, Xhairy1 antibody, Xlh1 antibody, hes1 antibody, hes family bHLH transcription factor 1 antibody, hairy and enhancer of split 1 (Drosophila) antibody, hes family bHLH transcription factor 4 antibody, hes family bHLH transcription factor 1 L homeolog antibody, HES1 antibody, Hes1 antibody, HES4 antibody, hes1.L antibody
    Background
    Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).
    UniProt
    P35428
    Pathways
    DNA Damage Repair
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