SIRT6 antibody (AA 276-305)

Catalog No. ABIN3032596

This Rabbit Polyclonal antibody specifically detects SIRT6 in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for SIRT6 antibody (AA 276-305) (ABIN3032596)

Target: SIRT6 (Sirtuin 6 (SIRT6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-SIRT6 Antibody

Binding Specificity: AA 276-305

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 276-305 from the human protein was used as the immunogen for this SIRT6 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the SIRT6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SIRT6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Alternative Name: SIRT6

Background: NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein (By similarity).

UniProt: Q8N6T7