SP1 antibody

Catalog No. ABIN3032703

The Mouse Monoclonal anti-SP1 antibody (Clone 1326CT463-109-176) (ABIN3032703) specifically detects SP1 in WB, ELISA, IF and FACS. The antibody is reactive with Human samples.

Quick Overview for SP1 antibody (ABIN3032703)

Target: SP1 (Sp1 Transcription Factor (SP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 1326CT463-109-176

Product Details anti-SP1 Antibody

Purification: Purified

Immunogen: This SP1 antibody was produced from a mouse immunized with recombinant Specificity Protein 1.

Isotype: IgG1 kappa

Application Details

Application Notes: Titration of the SP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Flow Cytometry: 1:25,Immunofluorescence: 1:25,Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SP1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for SP1

Target: SP1 (Sp1 Transcription Factor (SP1))

Alternative Name: SP1

Background: Specificity Protein 1/SP1 is a transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. [UniProt]

UniProt: P08047

Pathways: Regulation of Lipid Metabolism by PPARalpha, Myometrial Relaxation and Contraction