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YY1 antibody

The Mouse Monoclonal anti-YY1 antibody has been validated for WB and ELISA. It is suitable to detect YY1 in samples from Human.
Catalog No. ABIN3029666

Quick Overview for YY1 antibody (ABIN3029666)

Target

See all YY1 Antibodies
YY1 (YY1 Transcription Factor (YY1))

Reactivity

  • 90
  • 46
  • 30
  • 7
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  • 6
  • 4
  • 4
  • 4
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  • 2
  • 2
  • 2
  • 1
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Human

Host

  • 76
  • 14
  • 1
Mouse

Clonality

  • 65
  • 26
Monoclonal

Conjugate

  • 62
  • 5
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
This YY1 antibody is un-conjugated

Application

  • 73
  • 32
  • 29
  • 14
  • 13
  • 11
  • 8
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  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
  • 1
Western Blotting (WB), ELISA

Clone

1183CT6-5-23-6
  • Purification

    Purified

    Immunogen

    Purified His-tagged protein was used to produced this monoclonal YY1 antibody.

    Isotype

    IgG2a
  • Application Notes

    Titration of the YY1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

    Restrictions

    For Research Use only
  • Format

    Liquid

    Buffer

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Aliquot the YY1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target

    YY1 (YY1 Transcription Factor (YY1))

    Alternative Name

    YY1

    Background

    Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3', some genes have been shown to contain a longer binding motif allowing enhanced binding, the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair, proposed to target the INO80 complex to YY1-responsive elements.

    UniProt

    P25490
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