Complement Factor I antibody

Catalog No. ABIN4955823

This Rabbit Polyclonal antibody specifically detects Complement Factor I in WB and FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for Complement Factor I antibody (ABIN4955823)

Target: Complement Factor I (CFI)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor I antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-Complement Factor I Antibody

Purification: Antigen affinity

Immunogen: Amino acids K19-D220 were used as the immunogen for the Factor I antibody.

Isotype: IgG

Application Details

Application Notes: Western blot: 0.1-0.5 μg/mL,FACS: 1-3 μg/10^6 cells

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Factor I antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Complement Factor I

Target: Complement Factor I (CFI)

Alternative Name: Complement Factor I / CFI

Background: Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.

UniProt: P05156

Pathways: Complement System